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SKU: AN00298HP_25μL-ES
HRP-conjugated Lamin A/C Monoclonal Antibody, 25 μL
Lamin A/C is also named as LMNA,or LMN1. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis,the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability,chromatin structure and gene expression. The lack of lamin A/C can be as a novel marker for undifferentiated embryonic stem cells and lamin A/C expression is as an early indicator of differentiation (PMID: 16179429). Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy,familial partial lipodystrophy,limb girdle muscular dystrophy,dilated cardiomyopathy,Charcot-Marie-Tooth disease,and Hutchinson-Gilford progeria syndrome. This protein has 4 isoforms produced by alternative splicing with the molecular weight of 74 kDa,65 kDa,70 kDa and 64 kDa. This antibody can recognize 4 isoforms of Lamin A/C.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1 mg/mL
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Calculated Molecular Weight:65kDa
Observed Molecular Weight:65-70kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles. Protected from prolonged exposure to light.
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Calculated Molecular Weight:65kDa
Dilution:WB 1:2500-1:5000
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Application:WB
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Research Areas:Signal Transduction;Tags and Cell Markers;Cancer;Cell Biology;Developmental Biology;Epigenetics and Nuclear Signaling;Biochemicals
Species Reactivity:Human
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Target Synonym:Prelamin-A/C;LMNA;LMN1;Lamin A/C
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Buffer:PBS with 0.1% procline 300,1% protective protein and 50% glycerol,pH7.4
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Clonality:Monoclonal
Conjugation:HRP
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