BT LAB

SKU: BT-E3173Hu-96T

Human Acetyl-CoA Carboxylase 2, ACACB ELISA Kit, 96T

Mitochondrial enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA and plays a central role in fatty acid metabolism (PubMed: 16854592, PubMed: 19236960, PubMed: 20457939, PubMed: 20952656, PubMed: 19900410, PubMed: 26976583). Catalyzes a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA (PubMed: 19236960, PubMed: 20457939, PubMed: 20952656, PubMed: 26976583). Through the production of malonyl-CoA that allosterically inhibits carnitine palmitoyltransferase 1 at the mitochondria, negatively regulates fatty acid oxidation (By similarity). Together with its cytosolic isozyme ACACA, which is involved in de novo fatty acid biosynthesis, promotes lipid storage (By similarity).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Application:ELISA

Detection Target:ACACB

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Detection Range: 0.05-30ng/ml

Research Areas:Others

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Assay Time:1h 30m

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