BT LAB

SKU: BT-E2011Hu-96T

Human Beclin-1, BECN1 ELISA Kit , 96T

Plays a central role in autophagy (PubMed: 23184933, PubMed: 28445460). Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (PubMed: 20643123, PubMed: 20208530, PubMed: 26783301). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms. Involved in endocytosis (PubMed: 25275521). Protects against infection by a neurovirulent strain of Sindbis virus (PubMed: 9765397). May play a role in antiviral host defense. Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Application:ELISA

Detection Target:BECN1

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Detection Range: 0.2-60ng/ml

Research Areas:Others

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Test Principle:Sandwich

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Assay Time:1h 30m

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