BT LAB

SKU: BT-E3880Hu-96T

Human Bromodomain Testis-specific Protein, BRDT ELISA Kit, 96T

Testis-specific chromatin protein that specifically binds histone H4 acetylated at 'Lys-5' and 'Lys-8' (H4K5ac and H4K8ac, respectively) and plays a key role in spermatogenesis (PubMed: 22464331, PubMed: 22901802). Required in late pachytene spermatocytes: plays a role in meiotic and post-meiotic cells by binding to acetylated histones at the promoter of specific meiotic and post-meiotic genes, facilitating their activation at the appropriate time (PubMed: 22901802). In the post-meiotic phase of spermatogenesis, binds to hyperacetylated histones and participates in their general removal from DNA (PubMed: 22901802). Also recognizes and binds a subset of butyrylated histones: able to bind histone H4 butyrylated at 'Lys-8' (H4K8ac), while it is not able to bind H4 butyrylated at 'Lys-5' (H4K5ac) (By similarity). Also acts as a component of the splicing machinery in pachytene spermatocytes and round spermatids and participates in 3'-UTR truncation of specific mRNAs in post-meiotic spermatids (By similarity). Required for chromocenter organization, a structure comprised of peri-centromeric heterochromatin.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:13.85ng/L

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Application:ELISA

Detection Target:BRDT

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Detection Range: 30-9000ng/L

Research Areas:Epigenetics and Nuclear Signaling

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Test Principle:Sandwich

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