BT LAB

SKU: BT-E2440Hu-96T

Human Cytochrome P450 11B2, Mitochondrial, ALDOS ELISA Kit, 96T

A cytochrome P450 monooxygenase that catalyzes the biosynthesis of adrenal mineralocorticoid aldosterone (PubMed: 11856349, PubMed: 23322723, PubMed: 1594605, PubMed: 9814506). Catalyzes three sequential oxidative reactions of 11-deoxycorticosterone/21-hydroxyprogesterone, namely 11-beta hydroxylation followed with two successive oxidations at C18 to yield 18-hydroxy and then 18-aldehyde derivatives, resulting in the formation of aldosterone (PubMed: 11856349, PubMed: 23322723, PubMed: 1594605, PubMed: 9814506). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin) (PubMed: 11856349, PubMed: 23322723, PubMed: 1594605, PubMed: 9814506).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:10.08ng/L

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Application:ELISA

Detection Target:CYP11B2

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Detection Range: 20-6000ng/L

Research Areas:Others

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Assay Time:1h 30m

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