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BT LAB
SKU: BT-E6458Hu-96T
Human Gamma-aminobutyric Acid Type B Receptor Subunit 2, GABBR2 ELISA Kit, 96T
Component of a heterodimeric G-protein coupled receptor for GABA, formed by GABBR1 and GABBR2 (PubMed: 9872316, PubMed: 9872744, PubMed: 15617512, PubMed: 18165688, PubMed: 22660477, PubMed: 24305054). Within the heterodimeric GABA receptor, only GABBR1 seems to bind agonists, while GABBR2 mediates coupling to G proteins (PubMed: 18165688). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase (PubMed: 10075644, PubMed: 10773016, PubMed: 24305054). Signaling inhibits adenylate cyclase, stimulates phospholipase A2, activates potassium Channels, inactivates voltage-dependent calcium-Channels and modulates inositol phospholipid hydrolysis (PubMed: 10075644, PubMed: 9872744, PubMed: 10906333, PubMed: 10773016). Plays a critical role in the fine-tuning of inhibitory synaptic transmission (PubMed: 9872744, PubMed: 22660477). Pre-synaptic GABA receptor inhibits neurotransmitter release by down-regulating high-voltage activated calcium Channels, whereas postsynaptic GABA receptor decreases neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials (PubMed: 9872316, PubMed: 10075644, PubMed: 9872744, PubMed: 22660477). Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception (Probable).
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Product Specification
Basic Information
Brands:BT LAB
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Place of Origin:China
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Sensitivity:5.63ng/L
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Application:ELISA
Detection Target:GABBR2
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Detection Range: 10-2000ng/L
Research Areas:Others
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Test Principle:Sandwich
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Assay Time:1h 30m
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