BT LAB

SKU: BT-E3262Hu-96T

Human Neurogenic Locus Notch Homolog Protein 2, NOTCH2 ELISA Kit, 96T

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed: 21378985, PubMed: 21378989). Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed: 29149593). Positively regulates self-renewal of liver cancer cells (PubMed: 25985737).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Application:ELISA

Detection Target:NOTCH2

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Detection Range: 0.5-100ng/ml

Research Areas:Others

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Assay Time:1h 30m

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