BT LAB

SKU: BT-E4240hu-96T

Human Selenoprotein N, SELN ELISA Kit, 96T

[Isoform 2]: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed: 25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed: 19557870, PubMed: 18713863). Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed: 21131290).

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:1.53ng/ml

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Application:ELISA

Detection Target:SELENON

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Detection Range: 3-900ng/ml

Research Areas:Others

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Assay Time:1h 30m

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