BT LAB

SKU: BT-E6297Hu-96T

Human Transcriptional Enhancer Factor TEF-1, TEAD1 ELISA Kit , 96T

Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:9.73ng/L

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Application:ELISA

Detection Target:TEAD1

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Detection Range: 20-4500ng/L

Research Areas:Others

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Assay Time:1h 30m

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