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SKU: E-AB-90631_120μL-ES
IFIT3 Polyclonal Antibody, 120 μL
IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:55kDa
Observed Molecular Weight:60kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:55kDa
Dilution:WB 1:500-1:2000
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Application:WB
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Research Areas:Immunology
Species Reactivity:Human;Mouse
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Target Synonym:IFIT3;CIG-49;GARG-49;IFI60;IFIT4;IRG2;ISG60;P60;RIG-G;cig41
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Buffer:PBS with 0.02% sodium azide,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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