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SKU: E-AB-52649_120μL-ES
IGHA1 Polyclonal Antibody, 120 μL
Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268). Ig alpha is the major immunoglobulin class in body secretions (PubMed:2241915).
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:50-1:300
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Application:IHC
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Research Areas:Cancer;Immunology
Species Reactivity:Human
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Target Synonym:FLJ14473;FLJ35065;FLJ35500;FLJ36402;FLJ39698;FLJ40001;FLJ41548;FLJ41552;FLJ41789;FLJ43248;FLJ43594;FLJ44293;FLJ46028;FLJ46621;FLJ46724;FLJ46811;FLJ46824;FLJ90170;Ig alpha 1 chain C region;IgA1;IGHA1;immunoglobulin heavy constant alpha 1;MGC102857
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Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
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