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SKU: E-AB-52592_200μL-ES
IMPA1 Polyclonal Antibody, 200 μL
This gene encodes an enzyme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Calculated Molecular Weight:30 kDa
Observed Molecular Weight:Refer to figures
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:30 kDa
Dilution:WB 1:500-1:2000
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Application:WB
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Research Areas:Cancer;Metabolism;Neuroscience;Signal transduction
Species Reactivity:Human;Mouse;Rat
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Target Synonym:IMP 1;IMP;IMPA 1;IMPA;IMPA1;IMPA1;IMPase 1;IMPase;Inositol 1(or 4) monophosphatase;Inositol monophosphatase 1;Inositol monophosphatase;Inositol(myo) 1(or 4) monophosphatase 1;Inositol-1(or 4)-monophosphatase 1;Lithium sensitive myo inositol monophosphatase A1;Lithium-sensitive myo-inositol monophosphatase A1
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Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
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Conjugation:Unconjugated
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