Elabscience

SKU: E-AB-70200_120μL-ES

INPP5D Polyclonal Antibody, 120 μL

This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. The protein is also partly localized to the nucleus, where it may be involved in nuclear inositol phosphate signaling processes. Overall, the protein functions as a negative regulator of myeloid cell proliferation and survival. Mutations in this gene are associated with defects and cancers of the immune system. Alternative splicing of this gene results in multiple transcript variants.

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:China

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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

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Concentration:430 μg/mL

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Shelf Life:12 months

Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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Dilution:IHC 1:200-1:1000

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Application:IHC

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Research Areas:Cancer; Immunology; Signal Transduction

Species Reactivity:Mouse; Rat

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Target Synonym:Inositol polyphosphate 5 phosphatase of 145kDa;4;5-trisphosphate 5-phosphatase 1;hp51CN;Inositol polyphosphate 5 phosphatase 145kDa;Inositol polyphosphate 5 phosphatase;Inositol polyphosphate-5-phosphatase of 145 kDa;INPP5D;MGC104855;MGC142140;MGC142142;p150Ship;Phosphatidylinositol 3;4;5 trisphosphate 5 phosphatase 1;Phosphatidylinositol-3;SH2 containing inositol phosphatase isoform b;SH2 domain containing inositol 5' phosphatase 1;SH2 domain containing inositol phosphatase 1;SH2 domain-containing inositol phosphatase 1;SH2 domain-containing inositol-5''-phosphatase 1;SHIP-1;SHIP1;SHIP1;Signaling inositol polyphosphate 5 phosphatase SIP 145;SIP-145;SIP145

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Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4

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Clonality:Polyclonal

Conjugation:Unconjugated

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