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SKU: E-AB-92402_120μL-ES
(KO Validated) STAT5B Polyclonal Antibody, 120 μL
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:89kDa
Observed Molecular Weight:92KDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:89kDa
Dilution:WB 1:500-1:2000;IHC 1:50-1:100;IF 1:50-1:200
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Application:WB;IHC;IF
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Research Areas:Cancer;Epigenetics and Nuclear Signaling;Metabolism;Signal Transduction
Species Reactivity:Human;Mouse;Rat
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Target Synonym:STAT5B; STAT5; signal transducer and activator of transcription 5B
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Buffer:PBS with 0.05% proclin300,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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