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SKU: E-AB-70262_120μL-ES
MGMT Polyclonal Antibody, 120 μL
MGMT (O6-methylguanine-DNA methyltransferase) is transcriptionally activated in response to DNA damage and functions to repair mutagenic and cytotoxic O6-alkylguanine lesions caused by carcinogens or cytostatic drugs. MGMT induction by ionising radiation does not occur in p53-deficient mice, suggesting that MGMT induction may require p53. Similarly, MGMT mRNA and protein were shown to be inducible by ionising radiation, only in cell lines that express functional p53, and not in cell lines that do not express wild type p53. In contrast, high MGMT activity was associated with the presence of mutant p53, in a study of oral cancer cell lines. Similarly, MGMT activity was significantly lower in ovarian tumors with wildtype p53 than in tumors with mutant p53, supporting the view that wildtype p53 down-regulates the basal MGMT promoter.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:260 μg/mL
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:100-1:500
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Application:IHC
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Research Areas:Cancer; Epigenetics and Nuclear Signaling
Species Reactivity:Mouse; Rat
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Target Synonym:6 O methylguanine DNA methyltransferase;6-O-methylguanine-DNA methyltransferase;Agat;AGT;AI267024;EC 2.1.1.63;Methylated DNA protein cysteine methyltransferase;Methylated-DNA--protein-cysteine methyltransferase;Methylguanine DNA methyltransferase;MGC107020;MGMT;MGMT;O 6 methylguanine DNA alkyltransferase;O 6 methylguanine DNA methyltransferase;O-6-methylguanine-DNA methyltransferase;O-6-methylguanine-DNA-alkyltransferase
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Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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