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SKU: E-AB-52771_60μL-ES
NGEF Polyclonal Antibody, 60 μL
Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Calculated Molecular Weight:82 kDa
Observed Molecular Weight:Refer to figures
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:82 kDa
Dilution:WB 1:500-1:2000;IHC 1:30-1:150
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Application:WB;IHC
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Research Areas:Neuroscience;Signal transduction
Species Reactivity:Human;Mouse;Rat
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Target Synonym:ARHGEF27;Eph receptor-interacting exchange protein;Eph-interacting exchange protein;EPHEXIN;Ephexin-1;Guanine nucleotide exchange factor; neuronal;Neuronal guanine nucleotide exchange factor;Ngef;NGEF
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Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
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Conjugation:Unconjugated
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