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SKU: E-AB-70211_60μL-ES
NPHS1 Polyclonal Antibody, 60 μL
This gene encodes a member of the immunoglobulin family of cell adhesion molecules that functions in the glomerular filtration barrier in the kidney. The gene is primarily expressed in renal tissues, and the protein is a type-1 transmembrane protein found at the slit diaphragm of glomerular podocytes. The slit diaphragm is thought to function as an ultrafilter to exclude albumin and other plasma macromolecules in the formation of urine. Mutations in this gene result in Finnish-type congenital nephrosis 1, characterized by severe proteinuria and loss of the slit diaphragm and foot processes.In Western blots, nephrin antibodies generated against the two terminal extracellular Ig domains of recombinant human nephrin recognized a 180-kDa protein in lysates of human glomeruli and a 150-kDa protein in transfected COS-7 cell lysates.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1.3 mg/mL
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:1000-1:2000
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Application:IHC
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Research Areas:Cancer; Signal Transduction
Species Reactivity:Mouse
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Target Synonym:CNF;Nephrin;Nephrosis 1 congenital Finnish type;Nephrosis 1;congenital;Finnish type (nephrin);NPHN;NPHN;NPHS 1;Nphs1;Renal glomerulus specific cell adhesion receptor;Renal glomerulus-specific cell adhesion receptor
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Buffer:PBS with 0.02% sodium azide, 1% protective protein and 50% glycerol, pH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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