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SKU: E-AB-52172_60μL-ES
PPM1D Polyclonal Antibody, 60 μL
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. The expression of this gene is induced in a p53-dependent manner in response to various environmental stresses. While being induced by tumor suppressor protein TP53/p53, this phosphatase negatively regulates the activity of p38 MAP kinase, MAPK/p38, through which it reduces the phosphorylation of p53, and in turn suppresses p53-mediated transcription and apoptosis. This phosphatase thus mediates a feedback regulation of p38-p53 signaling that contributes to growth inhibition and the suppression of stress induced apoptosis. This gene is located in a chromosomal region known to be amplified in breast cancer. The amplification of this gene has been detected in both breast cancer cell line and primary breast tumors, which suggests a role of this gene in cancer development.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:50-1:300
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Application:IHC
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Research Areas:Cancer;Signal transduction
Species Reactivity:Human;Mouse
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Target Synonym:EC 3.1.3.16;p53 induced protein phosphatase 1;p53-induced protein phosphatase 1;PP2C delta;PP2C-delta;PP2CD;Ppm1d;PPM1D;Protein phosphatase 1D;protein phosphatase 1D magnesium-dependent delta isoform ;Protein phosphatase 2C delta isoform;Protein phosphatase 2C isoform delta;Protein phosphatase magnesium dependent 1 delta;Protein phosphatase magnesium-dependent 1 delta;Protein phosphatase Mg2+/Mn2+ dependent 1D;Protein phosphatase Wip1;Wild type p53 induced phosphatase 1;WIP 1;WIP1
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Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
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Conjugation:Unconjugated
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