BT LAB

SKU: BT-E0587Ra-96T

Rat Glucocorticoid Receptor, GR ELISA Kit, 96T

Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed: 12917342). Plays a role in rapid mRNA degradation by binding to the 5' UTR of target mRNAs and interacting with PNRC2 in a ligand-dependent manner which recruits the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (By similarity). Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth (By similarity). [Isoform A]: Has transcriptional activation and repression activity. Mediates glucocorticoid-induced apoptosis. Promotes accurate chromosome segregation during mitosis. May act as a tumor suppressor. May play a negative role in adipogenesis through the regulation of lipolytic and antilipogenic gene expression.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:5.32ng/L

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Application:ELISA

Detection Target:NR3C1

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Detection Range: 10-2000ng/L

Research Areas:Epigenetics and Nuclear Signaling

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Assay Time:1h 30m

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