BT LAB

SKU: BT-E0403Ra-96T

Rat Granzymes B, GZMS-B ELISA Kit, 96T

Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

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Product Specification

Basic Information

Brands:BT LAB

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Place of Origin:China

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Sensitivity:3.29ng/L

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Application:ELISA

Detection Target:GZMB

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Detection Range: 7-1500ng/L

Research Areas:Others

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Reactivity:Rat

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Assay Time:1h 30m

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