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BT LAB
SKU: BT-AP12244-50ul
RBL2(Phospho Ser952) Rabbit Polyclonal Antibody, 50ul
Key regulator of entry into cell division. Directly involved in heterochromatin formation by maintaining overall chromatin structure and| in particular| that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV420H1 and SUV420H2| leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Probably acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters. Potent inhibitor of E2F-mediated trans-activation| associates preferentially with E2F5. Binds to cyclins A and E. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. May act as a tumor suppressor.|miscellaneous:G0-restricted expression.|PTM:During G0 and early G1 phase of the cell cycle| phosphorylated on Ser-639 and on 5 sites within the domain B. Phosphorylation on Ser-672 in G1 leads to its ubiquitin-dependent proteolysis.|Belongs to the retinoblastoma protein (RB) family.|subunit:Interacts with AATF. Interacts with SUV420H1 and SUV420H2 (By similarity). Component of the DREAM complex (also named LINC complex) at least composed of E2F4| E2F5| LIN9| LIN37| LIN52| LIN54| MYBL1| MYBL2| RBL1| RBL2| RBBP4| TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9| LIN37| LIN52 and LIN54 form a subcomplex that binds to MYBL2. Interacts with RINT1.|
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Product Specification
Basic Information
Brands:BT LAB
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Place of Origin:China
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Concentration:1 mg/ml
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Storage:-20°C for 1 year
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Features and Capabilities
Application:WB, ELISA
Detection Target:RBL2
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Research Areas:Cancer; Cell biology; Epigenetics and nuclear signaling
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Reactivity:Human, Mouse, Rat
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Clonality:Polyclonal
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Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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