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SKU: E-AB-81539_50μL-ES
Recombinant cAMP Protein Kinase Catalytic Subunit Monoclonal Antibody, 50 μL
This gene encodes one of the catalytic subunits of protein kinase A, which exists as a tetrameric holoenzyme with two regulatory subunits and two catalytic subunits, in its inactive form. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. cAMP-dependent phosphorylation of proteins by protein kinase A is important to many cellular processes, including differentiation, proliferation, and apoptosis. Constitutive activation of this gene caused either by somatic mutations, or genomic duplications of regions that include this gene, have been associated with hyperplasias and adenomas of the adrenal cortex and are linked to corticotropin-independent Cushing's syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. Tissue-specific isoforms that differ at the N-terminus have been described, and these isoforms may differ in the post-translational modifications that occur at the N-terminus of some isoforms.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:300 μg/mL
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Calculated Molecular Weight:41kDa
Observed Molecular Weight:41kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:41kDa
Dilution:WB 1:1000-1:2000;IHC 1:50-1:100;IF 1:50-1:100
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Application:WB;IHC-P;IF;IP
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Research Areas:Cancer; Metabolism; Signal Transduction
Species Reactivity:Human; Mouse; Rat
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Target Synonym:cAMP dependent protein kinase alpha catalytic subunit;cAMP dependent protein kinase beta catalytic subunit;cAMP dependent protein kinase catalytic beta subunit isoform 4ab;cAMP dependent protein kinase catalytic subunit alpha;cAMP dependent protein kinase catalytic subunit alpha;isoform 1;cAMP dependent protein kinase catalytic subunit beta;cAMP-dependent protein kinase catalytic subunit alpha;KAPCA;PKA C alpha;PKA C beta;PKA C-alpha;PKACA;PKACB;PPNAD4;PRKACA;PRKACAA;PRKACB;Protein kinase A catalytic subunit alpha;Protein kinase A catalytic subunit;Protein kinase A catalytic subunit beta;Protein kinase cAMP dependent catalytic alpha;Protein kinase cAMP dependent catalytic beta
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Buffer:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
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Clonality:Rabbit Monoclonal
Conjugation:Unconjugated
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