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SKU: E-AB-81552_50μL-ES
Recombinant Doublecortin Monoclonal Antibody, 50 μL
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, cognitive disability, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain" syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:300 μg/mL
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Calculated Molecular Weight:41kDa
Observed Molecular Weight:41kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:41kDa
Dilution:WB 1:500-1:1000
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Application:WB
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Research Areas:Cancer; Neuroscience; Tags and Cell Markers
Species Reactivity:Rat
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Target Synonym:DBCN;Dbct;DC;DCX;DCX;Doublecortex;Doublin;FLJ51296;Lis X;Lis-X;Lissencephalin X;Lissencephalin-X;Lissencephaly X linked;Lissencephaly X linked doublecortin;LISX;Neuronal migration protein doublecortin;OTTHUMP00000023859;OTTHUMP00000023860;OTTHUMP00000216315;OTTHUMP00000216316;SCLH;XLIS
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Buffer:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
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Clonality:Rabbit Monoclonal
Conjugation:Unconjugated
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