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SKU: E-AB-81512_50μL-ES
Recombinant SQSTM1/p62 Monoclonal Antibody, 50 μL
Sequestosome 1 (SQSTM1/p62) is a multifunctional adaptor protein implicated in selective autophagy,cell signaling pathways,and tumorigenesis. p62 has been implicated in shuttling ubiquitinated and sometimes aggregated proteins for autophagic degradation. As a autophagy-specific substrate,p62 is degraded during the autophagic process,which makes intracellular level of p62 as a marker for autophagy flux. p62 is at the cross-roads of several signaling pathways including Ras/ Raf/ MAPK and NFκB and plays important role in cancer. p62 is a component of inclusion bodies/ protein aggregates found in human diseases,including Huntington's disease,Alzheimer's disease,Parkinson's disease in the brain,and nephropathic cystinosis in kidney (22074114,22860231,22714671). The molecular weight of p62 is predicted as 48/ 38 kDa,while western blot analyses using this antibody demonstrate the major band around 60-62 kDa in various tissues.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:300 μg/mL
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Calculated Molecular Weight:48kDa
Observed Molecular Weight:62kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:48kDa
Dilution:WB 1:500-1:1000
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Application:WB
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Research Areas:Cancer; Cardiovascular; Epigenetics and Nuclear Signaling; Metabolism; Signal Transduction
Species Reactivity:Human
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Target Synonym:A170;DMRV;EBI 3 associated protein of 60 kDa;EBI 3 associated protein p60;EBI3 associated protein of 60 kDa;EBI3 associated protein p60;EBI3-associated protein of 60 kDa;EBIAP;FTDALS3;MGC127197;ORCA;OSF-6;Osi;OSIL;Oxidative stress induced like;p60;p62;p62B;Paget disease of bone 3;PDB 3;PDB3;Phosphotyrosine independent ligand for the Lck SH2 domain of 62 kDa;Phosphotyrosine independent ligand for the Lck SH2 domain p62;Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa;PKC-zeta-interacting protein;Protein kinase C-zeta-interacting protein;Sequestosome 1;Sequestosome-1;SQSTM 1;SQSTM;Sqstm1;STAP;STONE14;Ubiquitin binding protein p62;Ubiquitin-binding protein p62;ZIP 3;ZIP;ZIP3
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Buffer:50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% protective protein
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Clonality:Rabbit Monoclonal
Conjugation:Unconjugated
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