RNase III,1KU

Brands:Solarbio

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Place of Origin:China

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Shipping:Ice bag

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Shelf Life:2 years under -20℃

Storage:-20℃

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Research Areas:Exonuclease

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Test Principle:Ribonuclease III (RNase III) is a double-stranded RNA (dsRNA)-specific ribonuclease derived from Escherichia coli. It is incapable of hydrolyzing DNA or single-stranded RNA. In the presence of manganese ions (Mn2?)，RNase III specifically cleaves long dsRNA into small interfering RNAs (siRNAs) of approximately 18-25 base pairs (bp). These siRNAs possess a 3’-hydroxyl terminus with 2 to 3 overhanging bases. The cleavage products are structurally similar to those generated by Dicer，and this enzyme is widely applied in researches including RNA interference，gene expression regulation，gene silencing and target validation.

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