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SKU: E-AB-52933_20μL-ES
SETDB1 Polyclonal Antibody, 20 μL
SETDB1,also named as ESET,KIAA0067 and KMT1E,belongs to the histone-lysine methyltransferase family. It is a SET domain protein with histone H3-K9-specific methyltransferase activity. H3 'Lys-9' trimethylation is coordinated with DNA methylation and represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1,CBX3 and/or CBX5) proteins to methylated histones. SETDB1 mainly functions in euchromatin regions,thereby playing a central role in the silencing of euchromatic genes. It probably forms a complex with MBD1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Its activity is dependent on MBD1 and is heritably maintained through DNA replication by being recruited by CAF-1. SETDB1 regulates histone methylation,gene silencing,and transcriptional repression. It has been identified as a target for treatment in Huntington Disease,given that gene silencing and transcription dysfunction likely play a role in the disease pathogenesis.
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Product Specification
Basic Information
Brands:Elabscience
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Place of Origin:China
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:50-1:300
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Application:IHC
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Research Areas:Cancer;Epigenetics and Nuclear Signaling
Species Reactivity:Human;Mouse
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Target Synonym:AU022152;EC 2.1.1.43;ERG-associated protein with SET domain;ESET;H3 K9 HMTase 4;H3-K9-HMTase 4;H3-K9-HMTase4;Histone H3 K9 methyltransferase 4;Histone H3-K9 methyltransferase 4;Histone-lysine N-methyltransferase SETDB1;KG1T;KIAA0067;KMT1E;Lysine N-methyltransferase 1E;MGC90670;mKIAA0067;SET domain bifurcated 1;Set domain protein;bifurcated;1;SETB1;Setdb1
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Buffer:PBS with 0.05% NaN3 and 40% Glycerol,pH7.4
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