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BT LAB
SKU: BT-AP08338-20ul
Skp2 p45 Polyclonal Antibody, 20ul
SKP2 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. S-phase kinase-associated protein 2 encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms.
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Product Specification
Basic Information
Brands:BT LAB
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Place of Origin:China
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Concentration:1 mg/ml
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Storage:-20°C for 1 year
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Application:WB, IHC-p, IF, ELISA
Detection Target:SKP2
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Research Areas:Cell Biology
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Reactivity:Human
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Clonality:Polyclonal
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Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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