Elabscience

SKU: E-AB-92031_60μL-ES

SLC12A3 Polyclonal Antibody, 60 μL

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

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Product Specification

Basic Information

Brands:Elabscience

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Place of Origin:China

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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

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Concentration:1mg/mL

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Observed Molecular Weight:100-170KDa

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Shelf Life:12 months

Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

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Dilution:WB 1:500-1:2000

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Application:WB

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Research Areas:Signal Transduction;Cardiovascular;Metabolism

Species Reactivity:Human;Mouse;Monkey

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Target Synonym:NCC;NCCT;TSC;SLC12A3

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Buffer:PBS with 0.01% thiomersal,50% glycerol,pH7.3.

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Clonality:Polyclonal

Conjugation:Unconjugated

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