- Specification
- Downloads
- Reviews
€288,00
ADD TO CART
SKU: E-AB-34159_120μL-ES
SMAD4 Polyclonal Antibody, 120 μL
This gene encodes a member of the Smad family of signal transduction proteins. Smad proteins are phosphorylated and activated by transmembrane serine-threonine receptor kinases in response to TGF-beta signaling. The product of this gene forms homomeric complexes and heteromeric complexes with other activated Smad proteins, which then accumulate in the nucleus and regulate the transcription of target genes. This protein binds to DNA and recognizes an 8-bp palindromic sequence (GTCTAGAC) called the Smad-binding element (SBE). The Smad proteins are subject to complex regulation by post-translational modifications. Mutations or deletions in this gene have been shown to result in pancreatic cancer, juvenile polyposis syndrome, and hereditary hemorrhagic telangiectasia syndrome. SMAD4 (SMAD Family Member 4) is a Protein Coding gene. Diseases associated with SMAD4 include Myhre Syndrome and Polyposis, Juvenile Intestinal. Among its related pathways are PEDF Induced Signaling and Validated targets of C-MYC transcriptional repression. GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and sequence-specific DNA binding. An important paralog of this gene is SMAD9.
- Regular price
- €288,00 EUR
- Sale price
- €288,00 EUR
- Regular price
-
ADD TO CART
Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
Warranty:
Safety Performance:
Protection Class:
Sterile Status:
Reconstitution:
Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
Battery:
Battery Service Life:
Component:
Technical Specifications
Capacity:
Concentration:
Dimension [D×W×H]:
Diameter:
Length:
Width:
High:
Volume:
Volume Range:
Speed:
Speed Range:
Max.Speed:
Max. RCF:
Temperature Range:
Operating Temperature Range:
Permissible Ambient Temperature :
Permissible Relative Humidity:
Input voltage:
Power Requirements:
Voltage/Frequency:
Sensitivity:
Specificity:
Precision:
Speed Accuracy:
Volume Accuracy:
Particle Size:
Pore Size:
Binding Capacity:
Calculated Molecular Weight:60kDa
Observed Molecular Weight:60kDa
Purity:
Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
Random Error:
Acceleration/Braking time:
Aspiration Speed:
Calculated Molecular Weight:60kDa
Dilution:IHC 1:100-1:300;IF 1:200-1:1000
Driving Motor DC motor:
Em:
Ex:
Endotoxin:
Flow rate [liquid]:
Features and Capabilities
Application:IHC-p;IF
Detection Target:
Detection Type:
Detection Range:
Research Areas:Cancer;Cardiovascular;Epigenetics and Nuclear Signaling;Metabolism;Signal Transduction;Stem Cells
Species Reactivity:Human;Mouse;Rat;Monkey
Reactivity:
Target Synonym:(Small) Mothers Against Decapentaplegic;Deleted in Pancreatic Carcinoma 4;Deleted in Pancreatic Carcinoma;Deleted in pancreatic carcinoma locus 4;Deletion target in pancreatic carcinoma 4;DPC 4;DPC4;hSMAD4;JIP;MAD homolog 4;MAD mothers against decapentaplegic Drosophila homolog 4;MAD mothers against decapentaplegic homolog 4;MADH 4;MADH4;Med;Medea;Mothers against decapentaplegic homolog 4;Mothers against decapentaplegic;Drosophila;homolog of;4;Mothers against DPP homolog 4;MYHRS;OTTHUMP00000163548;SMA- and MAD-related protein 4;SMAD 4;SMAD family member 4;SMAD mothers against DPP homolog 4;SMAD4;SMAD4
Test Principle:
Quantitative/Qualitative :
Result Type:
Materials :
Assay Time:
Autoclave component:
Available Rotor Adapters:
Binding Capacity:
Bio-activity:
Bottom Shape:
Bottom Type:
Buffer:PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4
Cap Color:
Clonality:Polyclonal
Conjugation:Unconjugated
Coupled Ligand:
Cover Type:
Detection Instrument :
Dispensing Speed:
Display:
Form:
Formulation:
Graduation:
Growth Area:
Powered by Bioz