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SKU: E-AB-92465_200μL-ES
SMC5 Polyclonal Antibody, 200 μL
Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres cell lines and mediates sumoylation of shelterin complex (telosome components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; the function seems to be independent of SMC6. SMC5-SMC6 complex may prevent transcription of episomal DNA, such as circular viral DNA genome.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:1mg/mL
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Calculated Molecular Weight:128kDa
Observed Molecular Weight:132kDa
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Calculated Molecular Weight:128kDa
Dilution:WB 1:1000-1:3000
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Application:WB
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Research Areas:Cell Biology;Epigenetics and Nuclear Signaling
Species Reactivity:Human;Mouse;Rat
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Target Synonym:SMC5;SMC5L1
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Buffer:PBS with 0.01% thiomersal,50% glycerol,pH7.3.
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Clonality:Polyclonal
Conjugation:Unconjugated
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