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SKU: E-AB-11600_200μL-ES
SRGAP3 Polyclonal Antibody, 200 μL
SRGAP3 is a 1099 amino acid protein containing 1 FCH domain, 1 Rho-GAP domain and 1 SH3 domain. Expressed highly in brain, and in lower levels in kidney, WRP is thought to play a role in cell migration through its interaction with Cdc42 and Rac1. Cdc42 and Rac1 are two intracellular signaling proteins that regulate the multistep cell migration process. WRP downregulates Cdc42 and Rac1 activity, thereby impairing actin and microtubule dynamics, the formation of protrusions, and total cell migration. Defects in the gene encoding WRP have been linked to severe idiopathic mental retardation. Three isoforms of WRP exist as a result of alternative splicing events.
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Product Specification
Basic Information
Brands:Elabscience
Model Number:
Place of Origin:China
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Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.
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Concentration:0.6 mg/mL
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Shelf Life:12 months
Storage:Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.
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Dilution:IHC 1:25-1:100
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Application:IHC
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Research Areas:Neuroscience;Signal Transduction
Species Reactivity:Human;Mouse
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Target Synonym:ARHGAP 14;ARHGAP14;Gbi;ME GAP;MEGAP;Mental disorder associated GAP;Mental disorder-associated GAP;Rho GTPase activating protein 14;Rho GTPase-activating protein 14;SLIT ROBO Rho GTPase activating protein 3;SLIT-ROBO Rho GTPase-activating protein 3;srGAP 2;srGAP 3;srGAP2;srGAP3;SRGP 2;SRGP2;SRGP3;WAVE associated Rac GTPase activating protein;WAVE-associated Rac GTPase-activating protein;WRP
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Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4
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Clonality:Polyclonal
Conjugation:Unconjugated
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